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Ολοκληρωμένο
The role of Nef in chronic immune activation and the pathogenesis on HIV-1 and HIV-2 infections
ΧρηματοδότηςUK Research and Innovation
Συνεισφορά χρηματοδότη 81.036,00 £
Διάρκεια01 Φεβ 2005 - 29 Ιουν 2008
Χρηματοδοτείται απόMRC
Κωδικός έργουMC_U190085854
Εντολή ανοιχτής πρόσβασηςΔημοσιεύσεις: ΌχιΕρευνητικά δεδομένα: Όχι
Αναγνωριστικά
Χρονοδιάγραμμα έργου100%
Περιγραφή
We are trying to understand why in general HIV-2 causes much less disease than HIV-1, even though some people with HIV-2 infection develop AIDS. We want to investigate whether there are important differences in one of the virus proteins called Nef between HIV-1 and HIV-2. We hypothesise that nef in HIV-2 is less likely to cause the immune system to over-react so-called immune activation so we are going to compare nef between HIV-1 and HIV-2, and between healthy people with HIV-2 and those with HIV-2 who have developed AIDS.
Εταίροι (1)
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We are trying to understand why in general HIV-2 causes much less disease than HIV-1, even though some people with HIV-2 infection develop AIDS. We want to investigate whether there are important differences in one of the virus proteins called Nef between HIV-1 and HIV-2. We hypothesise that nef in HIV-2 is less likely to cause the immune system to over-react so-called immune activation so we are going to compare nef between HIV-1 and HIV-2, and between healthy people with HIV-2 and those with HIV-2 who have developed AIDS.
