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PLASTINEX
Plasticity of intrinsic neuronal excitability in visual thalamic neurons
FunderFrench National Research Agency (ANR)
Funder Contribution €589,176.00
DurationFrom 15 Nov 2021
Project codeANR-21-CE16-0013
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Description
The dorsal lateral geniculate nucleus (dLGN), a primary recipient structure of retinal inputs, is traditionally considered to be just a relay of visual information. However recent works indicate that dLGN expresses functional plasticity following monocular deprivation (MD). Our proposal therefore consists in testing whether visual and spiking activity may modify neuronal excitability in dLGN neurons. Our consortium comprised of both experimentalists (electrophysiology, imaging, cell & molecular biology) and theoreticians propose to i) determine the mechanisms of long-term potentiation of intrinsic excitability in dLGN neurons, ii) define the structural correlate and the molecular mechanisms of the homeostatic plasticity of intrinsic excitability observed following MD and iii) build theoretical models of intrinsic plasticity. Our project will help provide new knowledge on the mechanisms underlying visual deficits.
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The dorsal lateral geniculate nucleus (dLGN), a primary recipient structure of retinal inputs, is traditionally considered to be just a relay of visual information. However recent works indicate that dLGN expresses functional plasticity following monocular deprivation (MD). Our proposal therefore consists in testing whether visual and spiking activity may modify neuronal excitability in dLGN neurons. Our consortium comprised of both experimentalists (electrophysiology, imaging, cell & molecular biology) and theoreticians propose to i) determine the mechanisms of long-term potentiation of intrinsic excitability in dLGN neurons, ii) define the structural correlate and the molecular mechanisms of the homeostatic plasticity of intrinsic excitability observed following MD and iii) build theoretical models of intrinsic plasticity. Our project will help provide new knowledge on the mechanisms underlying visual deficits.
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