SHALOMAC

Macrophages are immune cells playing a central role in maintaining tissue homeostasis and orchestrating repair after tissue injury. Macrophages can originate from two different pathways, deriving from embryonic precursors or from adult blood monocytes. While the biology of embryo-derived macrophages is well studied, the properties of monocyte-derived macrophages remain incompletely understood. In this project, we will focus on monocyte-derived macrophages that develop during sterile inflammation. Using in vitro models with human cells and in vivo models in mouse, we will address the differentiation mechanisms and functional roles of monocyte-derived macrophages during synovial joint inflammation and cutaneous wound healing. Our results should create new opportunities for ameliorating the treatment of autoimmune inflammation including rheumatoid arthritis.