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CAZIBD
Mucus-degrading enzymes and their role in intestinal inflammation
FunderFrench National Research Agency (ANR)
Funder Contribution €459,477.00
DurationFrom 01 Mar 2021
Project codeANR-20-CE14-0019
Identifiers
Description
Inflammatory bowel diseases (IBD) are modern diseases, with a rising incidence in the world. They are associated to perturbation of the intestinal microbiota, and to alteration and bacterial crossing of the mucus barrier. The aim of CAZIBD is to decipher, from the molecular to the microbiomic scales, the mucus-driven crosstalk between gut bacteria and their host in the context of IBD. A new strategy, combining physiopathology to metagenomics and enzymology, will be developed to study the host response to the breakdown of the mucus firewall, by a cocktail of new mucin-degrading enzymes isolated from the gut microbiome. Finally, the potential protective role of functional foods mimicking specific mucin structures will be assessed. In fine, this knowledge will lead to rationalize the dietary recommendations to prevent inflammatory flares incurred by patients with IBD, or to alleviate them.
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Inflammatory bowel diseases (IBD) are modern diseases, with a rising incidence in the world. They are associated to perturbation of the intestinal microbiota, and to alteration and bacterial crossing of the mucus barrier. The aim of CAZIBD is to decipher, from the molecular to the microbiomic scales, the mucus-driven crosstalk between gut bacteria and their host in the context of IBD. A new strategy, combining physiopathology to metagenomics and enzymology, will be developed to study the host response to the breakdown of the mucus firewall, by a cocktail of new mucin-degrading enzymes isolated from the gut microbiome. Finally, the potential protective role of functional foods mimicking specific mucin structures will be assessed. In fine, this knowledge will lead to rationalize the dietary recommendations to prevent inflammatory flares incurred by patients with IBD, or to alleviate them.
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