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LiverSoC
Bioengineered model of a true Liver Sinusoid on Chip for MAFLD drug testing
FunderFrench National Research Agency (ANR)
Funder Contribution €635,140.00
DurationFrom 05 Jan 2026
Project codeANR-25-CE52-6478
Identifiers
Description
This project aims to develop a bioengineered model of a liver sinusoid on a chip to study metabolic-associated steatotic liver disease (MASLD) and test potential drugs. MASLD is a growing global health concern characterized by abnormal fat accumulation in the liver. The project focuses on the role of liver sinusoidal endothelial cells (LSECs) in MASLD progression and aims to create a high-fidelity model that replicates the conditions of the disease. The model will enable researchers to: -Investigate the effects of flow disruption and inflammatory mediators on LSECs and hepatic stellate cells (HSCs). -Identify new therapeutic targets for MASLD. -Evaluate the efficacy of potential drug candidates. The team will use an interdisciplinary approach combining expertise in microfabrication, cell mechanobiology, and LSEC pathophysiology. The project's innovative nature, ambitious goals, and ability to address the critical need for better models to understand MASLD and develop effective therapeutic interventions make it a promising contribution to the field of MASLD research. Key features of the project include: -Development of a physiologically relevant Liver Sinusoid-on-a-Chip (LiverSoC) model. -Integration of LSECs and HSCs, which play crucial roles in MASLD progression. -Creation of a perfusable microvessel architecture that mimics the natural flow dynamics of the liver sinusoid. -Engineering of healthy vs. MASLD conditions to enable comparative studies. -Interdisciplinary collaboration between teams with expertise in microfabrication, cell mechanobiology, and LSEC pathophysiology. The project's success will have significant implications for the development of new treatments for MASLD, a disease with a growing global burden. By providing a more accurate and physiologically relevant in vitro system, the LiverSoC model will enable researchers to investigate the complex mechanisms underlying the disease and identify promising therapeutic targets.
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This project aims to develop a bioengineered model of a liver sinusoid on a chip to study metabolic-associated steatotic liver disease (MASLD) and test potential drugs. MASLD is a growing global health concern characterized by abnormal fat accumulation in the liver. The project focuses on the role of liver sinusoidal endothelial cells (LSECs) in MASLD progression and aims to create a high-fidelity model that replicates the conditions of the disease. The model will enable researchers to: -Investigate the effects of flow disruption and inflammatory mediators on LSECs and hepatic stellate cells (HSCs). -Identify new therapeutic targets for MASLD. -Evaluate the efficacy of potential drug candidates. The team will use an interdisciplinary approach combining expertise in microfabrication, cell mechanobiology, and LSEC pathophysiology. The project's innovative nature, ambitious goals, and ability to address the critical need for better models to understand MASLD and develop effective therapeutic interventions make it a promising contribution to the field of MASLD research. Key features of the project include: -Development of a physiologically relevant Liver Sinusoid-on-a-Chip (LiverSoC) model. -Integration of LSECs and HSCs, which play crucial roles in MASLD progression. -Creation of a perfusable microvessel architecture that mimics the natural flow dynamics of the liver sinusoid. -Engineering of healthy vs. MASLD conditions to enable comparative studies. -Interdisciplinary collaboration between teams with expertise in microfabrication, cell mechanobiology, and LSEC pathophysiology. The project's success will have significant implications for the development of new treatments for MASLD, a disease with a growing global burden. By providing a more accurate and physiologically relevant in vitro system, the LiverSoC model will enable researchers to investigate the complex mechanisms underlying the disease and identify promising therapeutic targets.
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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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