Copperation

"Copperation" project aims to develop and synthesize fluorescent ligands capable of selectively extract copper (I) ions (Cu) contained in the amyloids-ß peptides (Aß), thus inhibit the production of toxic reactive oxygen species (ROS) in the context of Alzheimer's disease. The fluorescence properties will allow (i) in cellulo complex localization studies of these molecules; (ii) mechanistic studies during the extraction processes of Cu from Aß and during the evaluation of the impact of the ligands on ROS production (in vitro and in cellulo). The ability of ligands to rebalance Cu between intra- and extracellular compartments for therapeutic purposes will also be studied, as well as their effects on restoring cell survival under or without oxidative stress.