ATHERSPECTRALCT

Atherosclerosis and its consequences remain the main cause of mortality in industrialized and developing nations. Spectral Photon Counting Computed Tomography (SPCCT) can detect and quantify accurately Gd by using the K-edge technique. AGuIX nanoparticles are composed of a polysiloxane matrix surrounded by Gd cyclic chelates. The regulatory toxicity tests have shown no evidence of toxicity on two different animal species and the nanoparticules have been accepted for a phase I clinical trial. Their easy functionalization by biomolecules can target Fibrin, VCAM or proto-elastin. The objective is to develop and perform, a very high spatial resolution non-invasive angiography, and quantitative myocardial perfusion evaluation using clinically available Gd nanosized and new developed particles based on the AGuIX platform. To increase the signal per nanoparticle, gadolinium and/or bismuth will be added on the nano-objectin order to detect, quantify and monitor in vivo non- invasively the evolution of atheroma and myocardial infarction. A comparison will be done between non targeted nanoparticles and nanoparticles functionalized to have an affinity for fibrin, VCAM or proto-elastin.