POTENTIAL

Enals are key molecules in organic chemistry. Their importance stems from their particular molecular structure featuring two reactive sites, a conjugated C=O double bond paired with a C=C double bond, which offers a plethora of potential reactivity pathways. Moreover, when considering ?-enolizable enals, it then becomes possible to carry out remote functionalization reactions on this remote position. However, despite many studies in this area, only a limited number of substituents can be selectively introduced at this ?-position. Furthermore, no methodology is known to date for functionalizing enals at the even more distant d-position. The aim of this project is to bring a solution to the major difficulties encountered in this field, namely: 1) Extend ?-functionalization to other substituents, including unactivated C(sp3) carbons and C(sp2) carbons. 2) Carry out various functionalizations in the d position of enals. 3) Investigate the enantioselective version of these transformations. The development of new photochemical and electrochemical methods will be essential to achieve the goals of this ambitious project.