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SPIRIT
Screening Protein Interaction with RNA by Innovative Technologies
FunderFrench National Research Agency (ANR)
Funder Contribution €505,011.00
DurationFrom 01 Nov 2022
Project codeANR-22-CE18-0029
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Description
We have recently discovered a new technology that uses microtubules as nanoplatforms to detect biomolecular interactions in cells. This technology is particularly effective in quantifying RNA:protein interactions for which other existing methods offer few alternatives. Here, we propose to develop this technology to screen small molecules to interfere with RNA:protein interactions related to pathological processes. To validate our strategy, we will use an integrative approach combining bionformatics, structural and cellular biology to target a specific RNA:protein complex involved in human cancer. We have already obtained the NMR structure of the RNA:protein complexe targets to probe the action of small molecules in vitro and identified few molecules targeting mRNA:protein interactions in cells. At the end of this project, our results could validate our innovative approach and reveal RNA:protein interactions as putative targets in human diseases.
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We have recently discovered a new technology that uses microtubules as nanoplatforms to detect biomolecular interactions in cells. This technology is particularly effective in quantifying RNA:protein interactions for which other existing methods offer few alternatives. Here, we propose to develop this technology to screen small molecules to interfere with RNA:protein interactions related to pathological processes. To validate our strategy, we will use an integrative approach combining bionformatics, structural and cellular biology to target a specific RNA:protein complex involved in human cancer. We have already obtained the NMR structure of the RNA:protein complexe targets to probe the action of small molecules in vitro and identified few molecules targeting mRNA:protein interactions in cells. At the end of this project, our results could validate our innovative approach and reveal RNA:protein interactions as putative targets in human diseases.
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