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MEIOBLOC
Causative genetic alterations in human meiotic arrest and their correction
FunderFrench National Research Agency (ANR)
Funder Contribution €647,853.00
DurationFrom 31 Mar 2023
Project codeANR-22-CE17-0059
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Description
Homogeneous meiotic arrest is a rare condition that prevents sperm formation or accelerated ovarian exhaustion, resulting in infertility for which there is no treatment today. Recent results confirm genetic heterogeneity, but there is currently no standardized description of the testicular phenotype, nor functional validation of the genetic variants identified. The objective of the MEIOBLOC project, following the establishment of a national network, is to better define the arrests of spermatogenesis and to confirm the functional impact of the male and female variants identified through the development of mouse and cell models. Finally, several gene therapy approaches aiming at restoring spermatogenesis in mouse models of meiotic arrest will be considered in order to evaluate the feasibility and safety of this approach for possible clinical application.
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Homogeneous meiotic arrest is a rare condition that prevents sperm formation or accelerated ovarian exhaustion, resulting in infertility for which there is no treatment today. Recent results confirm genetic heterogeneity, but there is currently no standardized description of the testicular phenotype, nor functional validation of the genetic variants identified. The objective of the MEIOBLOC project, following the establishment of a national network, is to better define the arrests of spermatogenesis and to confirm the functional impact of the male and female variants identified through the development of mouse and cell models. Finally, several gene therapy approaches aiming at restoring spermatogenesis in mouse models of meiotic arrest will be considered in order to evaluate the feasibility and safety of this approach for possible clinical application.
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