DelivrO2

Among the various elements present in organic molecules, oxygen plays a key role in many functional groups, and its isotopic labelling often provides determinant mechanistic evidences in chemical reactions and biological studies. Whereas using singlet oxygen (1O2) is a convenient strategy to incorporate oxygen atoms in organic compounds in extremely mild conditions, the direct transfer of the existing conditions involving large excesses of O2 is too costly for practical applications in isotopic oxygen labelling. In this context, the DelivrO2 project proposes the development and the use of new endoperoxides that will allow the efficient and temporally / spatially controlled releases of stoichiometric amounts of isotopically labelled [*O]1O2 for both synthetic and biological applications.