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chemosim
Rational design of chemosensory compounds targeting smell, taste and emotion
FunderFrench National Research Agency (ANR)
Funder Contribution €443,920.00
DurationFrom 02 Jan 2020
Project codeANR-19-CE07-0044
Identifiers
Description
This project is fundamental and highly multidisciplinary. It gathers academic experts in computational modeling, protein engineering, behavioral neuroscience, and a company expert in sensory analysis. Their research hypothesis is that numerical models can crack the code of chemosensory sensations. The project aims at predicting or synthesizing chemicals targeting given smells, tastes, or modulating our mood or emotions. They will use ligand-based and receptor-based numerical models to tentatively decode i/ how our brain uses receptors to perceive its chemical environment, and ii/ how chemical senses are encoded within odorants and tastants chemical properties. These properties can either belong to the perceptive field (smell and taste) but also to the hedonic field (like or dislike), itself wired to our mood or emotions. Here, in silico models will process data coming from different level, ranging from cellular to sensory levels.
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This project is fundamental and highly multidisciplinary. It gathers academic experts in computational modeling, protein engineering, behavioral neuroscience, and a company expert in sensory analysis. Their research hypothesis is that numerical models can crack the code of chemosensory sensations. The project aims at predicting or synthesizing chemicals targeting given smells, tastes, or modulating our mood or emotions. They will use ligand-based and receptor-based numerical models to tentatively decode i/ how our brain uses receptors to perceive its chemical environment, and ii/ how chemical senses are encoded within odorants and tastants chemical properties. These properties can either belong to the perceptive field (smell and taste) but also to the hedonic field (like or dislike), itself wired to our mood or emotions. Here, in silico models will process data coming from different level, ranging from cellular to sensory levels.
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