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Exploiting autophagy-lysosomal dysfunction of immune cells as therapeutic target in periodontal diseases
FunderFrench National Research Agency (ANR)
Funder Contribution €589,185.00
DurationFrom 01 Oct 2021
Project codeANR-21-CE17-0026
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Description
Periodontal diseases are inflammatory diseases of infectious origin. They are characterized by the destruction of tooth-supporting tissues and lead to tooth loss. The prevalence of periodontitis is high as such disease is found in more than 50% of the population worldwide with more than 10% presenting a severe form of the disease. The main part of periodontal tissue destruction is induced by the exacerbated and dysregulated host-immune response. In this context, the modulation of autophagy is one of the mechanisms developed by bacteria to hijack immune response, to invade and survive within cells. However, such bacterial strategy leads to sustained inflammation and cell apoptosis. Currently, periodontal treatments are not able to resolve efficiently the inflammation and to induce regeneration of the destroyed tissues. Therefore, development of innovative pharmacological strategy is instrumental. In this project, we propose to evaluate the effects of a systemic and local administration of the therapeutic peptide P140, a modulator of autophagy, on the periodontal inflammation in vitro and in vivo.This project will contribute to a better understanding of the biological mechanisms involved in the disease and will pave the way for an innovative way of management of periodontitis that will benefit to an important number of patients.
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Periodontal diseases are inflammatory diseases of infectious origin. They are characterized by the destruction of tooth-supporting tissues and lead to tooth loss. The prevalence of periodontitis is high as such disease is found in more than 50% of the population worldwide with more than 10% presenting a severe form of the disease. The main part of periodontal tissue destruction is induced by the exacerbated and dysregulated host-immune response. In this context, the modulation of autophagy is one of the mechanisms developed by bacteria to hijack immune response, to invade and survive within cells. However, such bacterial strategy leads to sustained inflammation and cell apoptosis. Currently, periodontal treatments are not able to resolve efficiently the inflammation and to induce regeneration of the destroyed tissues. Therefore, development of innovative pharmacological strategy is instrumental. In this project, we propose to evaluate the effects of a systemic and local administration of the therapeutic peptide P140, a modulator of autophagy, on the periodontal inflammation in vitro and in vivo.This project will contribute to a better understanding of the biological mechanisms involved in the disease and will pave the way for an innovative way of management of periodontitis that will benefit to an important number of patients.
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