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GMO-Phen
Cracking the role of RFRP3 in seasonal breeding with genome editing.
FunderFrench National Research Agency (ANR)
Funder Contribution €559,059.00
DurationFrom 01 Apr 2021
Project codeANR-20-CE14-0031
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Description
Most species exhibit seasonal breeding as an adaptive response to environmental changes. However, seasonal species mate either under short (e.g. sheep) or long days (e.g. hamster). We highlighted roles for the mammalian neuropeptides RFRP3 (RF-amide Related Peptide 3 encoded by the Npvf gene) and KISS1 (Kisspeptin), produced by hypothalamic neurons. In contrast to KISS1, the role of RFRP3 in seasonal breeding is unclear. We hypothesize that integration primarily occurs at the level of Npvf neurons, which then dictate species-specific seasonal breeding. The current project will investigate this in Syrian hamster and sheep. The aims are to provide evidence for the implication of the Npvf gene through CRISPR-Cas9 invalidation and to characterize RFRP3-producing neurons with respect to neurotransmitter expression and sex-steroid feedback using scRNAseq and to explore neuronal wiring between KISS1 and RFRP3 populations, as plausible substrates for opposite seasonal phenologies
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Most species exhibit seasonal breeding as an adaptive response to environmental changes. However, seasonal species mate either under short (e.g. sheep) or long days (e.g. hamster). We highlighted roles for the mammalian neuropeptides RFRP3 (RF-amide Related Peptide 3 encoded by the Npvf gene) and KISS1 (Kisspeptin), produced by hypothalamic neurons. In contrast to KISS1, the role of RFRP3 in seasonal breeding is unclear. We hypothesize that integration primarily occurs at the level of Npvf neurons, which then dictate species-specific seasonal breeding. The current project will investigate this in Syrian hamster and sheep. The aims are to provide evidence for the implication of the Npvf gene through CRISPR-Cas9 invalidation and to characterize RFRP3-producing neurons with respect to neurotransmitter expression and sex-steroid feedback using scRNAseq and to explore neuronal wiring between KISS1 and RFRP3 populations, as plausible substrates for opposite seasonal phenologies
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