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SENSICAV
Highly-Sensitive Cavitation Mapping for Advanced Monitoring of Ultrasound-Mediated Blood Brain Barrier Opening
FunderFrench National Research Agency (ANR)
Funder Contribution €654,466.00
DurationFrom 15 Jan 2025
Project codeANR-24-CE19-5885
Identifiers
Description
The blood-brain barrier (BBB) is a natural obstacle that prevents the passage of any external agent into the cells of brain tissue. This is one of the reasons why some therapies are inefficient, as this barrier also obstructs the pathway for therapeutic agents. Non-invasive and reversible solutions now exist to temporary permeabilize the BBB. Among them, focused ultrasound combined with the administration of microbubbles has shown a great potential for enhanced drug delivery into brain and is now evaluated in multiple clinical trials. The monitoring of the microbubble oscillation process (intensity and localization), known as cavitation, is essential to ensure BBB disruption while avoiding potential brain damages. Currently, non MRI-guided BBB opening systems are exclusively positioned using neuro-navigation, which leads to potential positioning errors related to registration errors. One of the simplest solutions for imaging in this specific context is to capture all the re-emitted ultrasound signals using multi-element arrays of ultrasound receivers. This technique, known as Passive Acoustic Mapping (PAM), is usually performed with conventional imaging arrays that are not optimized for this application. SENSICAV project aims to develop a very wide band (0.2 MHz to 2 MHz), multi-site PAM device and a methodology to monitor and locate in real time, at millimetric scales, the cavitation process during US-mediated BBB opening steps. Dedicated arrays (1D and 2D) based on very low noise ultrasonic sensor technologies will be developed, i.e., micromachined ultrasonic capacitive transducers (CMUT) integrating low noise electronic preamplifiers. More, we will rely on this ability to localize cavitation to refine and correct the positioning of the therapeutic transducer thanks to a robot-assisted approach.
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The blood-brain barrier (BBB) is a natural obstacle that prevents the passage of any external agent into the cells of brain tissue. This is one of the reasons why some therapies are inefficient, as this barrier also obstructs the pathway for therapeutic agents. Non-invasive and reversible solutions now exist to temporary permeabilize the BBB. Among them, focused ultrasound combined with the administration of microbubbles has shown a great potential for enhanced drug delivery into brain and is now evaluated in multiple clinical trials. The monitoring of the microbubble oscillation process (intensity and localization), known as cavitation, is essential to ensure BBB disruption while avoiding potential brain damages. Currently, non MRI-guided BBB opening systems are exclusively positioned using neuro-navigation, which leads to potential positioning errors related to registration errors. One of the simplest solutions for imaging in this specific context is to capture all the re-emitted ultrasound signals using multi-element arrays of ultrasound receivers. This technique, known as Passive Acoustic Mapping (PAM), is usually performed with conventional imaging arrays that are not optimized for this application. SENSICAV project aims to develop a very wide band (0.2 MHz to 2 MHz), multi-site PAM device and a methodology to monitor and locate in real time, at millimetric scales, the cavitation process during US-mediated BBB opening steps. Dedicated arrays (1D and 2D) based on very low noise ultrasonic sensor technologies will be developed, i.e., micromachined ultrasonic capacitive transducers (CMUT) integrating low noise electronic preamplifiers. More, we will rely on this ability to localize cavitation to refine and correct the positioning of the therapeutic transducer thanks to a robot-assisted approach.
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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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