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MEASURAGE
CONCEPTUAL FOUNDATIONS OF THE MEASUREMENT OF AGING
FunderFrench National Research Agency (ANR)
Funder Contribution €374,550.00
DurationFrom 01 Mar 2024
Project codeANR-23-CE54-0008
Identifiers
Description
Data on biological aging are accumulating without aging being a well-defined process. More specifically, a conceptual framework for measuring this process is lacking. Biological age is most often expressed as a deviation from the average chronological age in the population. This relies on three questionable assumptions of unicity of the reference class, the process, and the main effect of aging. More generally, the problem of measuring aging is to find a reflection of the degree of progression of a biological process, simple or composite, not defined over a particular subpopulation but over the whole species or many species, and not only reflecting the progression of age-related diseases. Whether clinical or biological, the available measures of aging (in particular, the Horvath clock, which expresses a seemingly universal biological signature) raise various interpretive problems that limit their usefulness. The working hypothesis of MEASURAGE is that a clarification and explication of the measurand of "aging" must proceed from the analysis of the problems of semantic confusion, metric indecision, ontological imprecision, mechanistic complexity and pragmatic multiplicity. MEASURAGE combines a conceptual analysis of the fundamental concepts of biogerontology (in its literature and practices) with a reflection on the complexity of the mechanisms of aging and an analysis rigorously conducted within the framework of an explicit biological and medical ontology.
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Data on biological aging are accumulating without aging being a well-defined process. More specifically, a conceptual framework for measuring this process is lacking. Biological age is most often expressed as a deviation from the average chronological age in the population. This relies on three questionable assumptions of unicity of the reference class, the process, and the main effect of aging. More generally, the problem of measuring aging is to find a reflection of the degree of progression of a biological process, simple or composite, not defined over a particular subpopulation but over the whole species or many species, and not only reflecting the progression of age-related diseases. Whether clinical or biological, the available measures of aging (in particular, the Horvath clock, which expresses a seemingly universal biological signature) raise various interpretive problems that limit their usefulness. The working hypothesis of MEASURAGE is that a clarification and explication of the measurand of "aging" must proceed from the analysis of the problems of semantic confusion, metric indecision, ontological imprecision, mechanistic complexity and pragmatic multiplicity. MEASURAGE combines a conceptual analysis of the fundamental concepts of biogerontology (in its literature and practices) with a reflection on the complexity of the mechanisms of aging and an analysis rigorously conducted within the framework of an explicit biological and medical ontology.
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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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