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HEPADIMAIT
MUCOSAL-ASSOCIATED INVARIANT T CELLS AT THE CROSS ROAD BETWEEN INFLAMMATION AND MICROBIOTA IN METABOLIC DYSFUNCTION AND NON-ALCOHOLIC FATTY LIVER DISEASE
FunderFrench National Research Agency (ANR)
Funder Contribution €616,457.00
DurationFrom 01 Jan 2020
Project codeANR-19-CE14-0041
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Description
The exacerbated inflammatory response is a major component of metabolic syndrome and contributes to fatty liver disease progression to fibrosis. Mucosal-associated T cells (MAIT) are an abundant T lymphocyte subset in blood, adipose tissue and liver, that recognizes bacterial-derived ligands. The consortium has shown that metabolic syndrome is associated with MAIT cell alterations and demonstrated their pro-inflammatory and pro-fibrogenic roles in the liver. HEPADIMAIT will focus on the link between MAIT cell functions, inflammation and microbiota-derived bacterial MAIT ligands, and the impact on metabolic dysfunction. We will also evaluate whether modulating MAIT cell functions may constitute a new therapeutic approach. The project combines studies in human samples, unique animal models and cell culture experiments. HEPADIMAIT is likely to pave the way for the design of novel MAIT-targeting therapies to prevent metabolic syndrome and associated fatty liver disease.
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The exacerbated inflammatory response is a major component of metabolic syndrome and contributes to fatty liver disease progression to fibrosis. Mucosal-associated T cells (MAIT) are an abundant T lymphocyte subset in blood, adipose tissue and liver, that recognizes bacterial-derived ligands. The consortium has shown that metabolic syndrome is associated with MAIT cell alterations and demonstrated their pro-inflammatory and pro-fibrogenic roles in the liver. HEPADIMAIT will focus on the link between MAIT cell functions, inflammation and microbiota-derived bacterial MAIT ligands, and the impact on metabolic dysfunction. We will also evaluate whether modulating MAIT cell functions may constitute a new therapeutic approach. The project combines studies in human samples, unique animal models and cell culture experiments. HEPADIMAIT is likely to pave the way for the design of novel MAIT-targeting therapies to prevent metabolic syndrome and associated fatty liver disease.
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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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