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ImSynPark
In vivo imaging of brain alpha-synuclein using chemical exchange saturation transfer: towards a new biomarker of Parkinson’s disease
FunderFrench National Research Agency (ANR)
Funder Contribution €673,078.00
DurationFrom 01 Jan 2026
Project codeANR-25-CE17-5285
Identifiers
Description
Parkinson’s disease is a multisystem progressive neurodegenerative disorder with pathological hallmarks, including dopaminergic neuronal degeneration in the nigrostriatal pathway, abnormal iron build-up and alpha synuclein protein accumulation forming Lewy body inclusions. Over the last years, neuroimaging methods have provided invaluable insights into some mechanisms as iron load and the neurodegeneration. However, still, no imaging method has yet been able to inform about the a synuclein aggregation and spreading. The aim of the ImSynPark project is to develop a chemical exchange saturation transfer magnetic resonance imaging (CEST) method for the in vivo quantification of brain alpha synuclein protein with clinically compatible acquisition times. CEST imaging, a part of what is known as metabolic MR imaging, can provide, with a good spatial resolution, an indirect in vivo quantification of proteins implied in several neurodegenerative disorders The originality of our approach consists in targeting new pathophysiological processes of PD by acquiring quantitative MRI data not currently available in national or international databases, and in developing complete protocols for processing these data. The project is built as a translational project starting by in vitro experiments right up to the first clinical tests using 3T and 7T MR machines. The project includes 3 main steps: in vitro experiments and calibrations, in vivo investigations using animal models and clinical tests. The project takes advantage of a unique pool of expertise: 3 research teams and 2 imaging platforms, both members of the France Life Imaging (FLI) network. The project merges three complementary topics: neurobiology, biophysics and image processing. All partners have the required experience to follow the roadmap and to respond to challenges of this project and produce a major breakthrough.
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Parkinson’s disease is a multisystem progressive neurodegenerative disorder with pathological hallmarks, including dopaminergic neuronal degeneration in the nigrostriatal pathway, abnormal iron build-up and alpha synuclein protein accumulation forming Lewy body inclusions. Over the last years, neuroimaging methods have provided invaluable insights into some mechanisms as iron load and the neurodegeneration. However, still, no imaging method has yet been able to inform about the a synuclein aggregation and spreading. The aim of the ImSynPark project is to develop a chemical exchange saturation transfer magnetic resonance imaging (CEST) method for the in vivo quantification of brain alpha synuclein protein with clinically compatible acquisition times. CEST imaging, a part of what is known as metabolic MR imaging, can provide, with a good spatial resolution, an indirect in vivo quantification of proteins implied in several neurodegenerative disorders The originality of our approach consists in targeting new pathophysiological processes of PD by acquiring quantitative MRI data not currently available in national or international databases, and in developing complete protocols for processing these data. The project is built as a translational project starting by in vitro experiments right up to the first clinical tests using 3T and 7T MR machines. The project includes 3 main steps: in vitro experiments and calibrations, in vivo investigations using animal models and clinical tests. The project takes advantage of a unique pool of expertise: 3 research teams and 2 imaging platforms, both members of the France Life Imaging (FLI) network. The project merges three complementary topics: neurobiology, biophysics and image processing. All partners have the required experience to follow the roadmap and to respond to challenges of this project and produce a major breakthrough.
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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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