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Salmo_prophages
CO-EVOLUTION OF PROPHAGE AND BACTERIAL GENOMES: PROPHAGE COOPTATION and LYSOGENIC CONVERSION in SALMONELLA
FunderFrench National Research Agency (ANR)
Funder Contribution €444,115.00
DurationFrom 01 Jan 2017
Project codeANR-16-CE12-0029
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Description
Temperate bacteriophages are bacterial viruses that can integrate their genome into their hosts. In the lysogenic state they are transmitted vertically without any requirement for a lytic cycle, as long as no stressful conditions are encountered. Under such a state, they provide new genetic material and thus influence the host genotype and phenotype, in particular through the acquisition of virulence and adaptive traits that are found in many human pathogens. Phage-encoded virulence factors influence bacterial pathogenicity in many different ways including increased fitness under infectious conditions. The Salmo_Prophages project combines large-scale bioinformatics to up to date molecular genetics to characterize prophage-encoded functions cooptation as well as the influence of lysogeny on Salmonella species genotypes and phenotypes. These themes are established and recognized as major expertise of our consortium. Together, this project based on the study of bacteriophage mediated horizontal gene transfer and host-phage genomes coevolution brings valuable perspectives to develop new diagnosis tools and treatment of infectious diseases.
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Temperate bacteriophages are bacterial viruses that can integrate their genome into their hosts. In the lysogenic state they are transmitted vertically without any requirement for a lytic cycle, as long as no stressful conditions are encountered. Under such a state, they provide new genetic material and thus influence the host genotype and phenotype, in particular through the acquisition of virulence and adaptive traits that are found in many human pathogens. Phage-encoded virulence factors influence bacterial pathogenicity in many different ways including increased fitness under infectious conditions. The Salmo_Prophages project combines large-scale bioinformatics to up to date molecular genetics to characterize prophage-encoded functions cooptation as well as the influence of lysogeny on Salmonella species genotypes and phenotypes. These themes are established and recognized as major expertise of our consortium. Together, this project based on the study of bacteriophage mediated horizontal gene transfer and host-phage genomes coevolution brings valuable perspectives to develop new diagnosis tools and treatment of infectious diseases.
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Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. Provider Academic Bibliometrics & Assessment Computational Utility Service Expiration Session Name greekSession Description Stores the user session ID for Academic Bibliometrics & Assessment Computational Utility Service. 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