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LIFEGRAFT
Innovation designed to evaluate and improve heart graft quality before transplantation
FunderFrench National Research Agency (ANR)
Funder Contribution €495,471.00
DurationFrom 01 Oct 2018
Project codeANR-18-CE18-0015
Identifiers
Description
The project leader invented a new device for hypothermic pulsed perfusion, named INOVAGRAFT (2 patents, Inserm Prize 2015 for Innovation), which would drastically enhance the duration of grafts transport. Associated with a new carrier of O2 derived from marine worms (HEMO2life®, patented by the company Hemarina), INOVAGRAFT could be at the origin of a paradigm shift in heart transplantation, with the possibilities: - (1) to greatly extend the preservation time, - (2) to allow the use of hearts from donors in circulatory arrest (Donor Cardiac Death). INOVAGRAFT- HEMO2life® would therefore partly overcome the dramatic shortage of cardiac grafts. INOVAGRAFT is an imaging compatible device that would also enable the evaluation of the graft viability by multimodal imaging: MRI, Ultrasound, X, and PET in order to characterize: - (a) edema and tissue hardening - (b) microperfusion and vascular permeability - (c) energy status of the graft.
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The project leader invented a new device for hypothermic pulsed perfusion, named INOVAGRAFT (2 patents, Inserm Prize 2015 for Innovation), which would drastically enhance the duration of grafts transport. Associated with a new carrier of O2 derived from marine worms (HEMO2life®, patented by the company Hemarina), INOVAGRAFT could be at the origin of a paradigm shift in heart transplantation, with the possibilities: - (1) to greatly extend the preservation time, - (2) to allow the use of hearts from donors in circulatory arrest (Donor Cardiac Death). INOVAGRAFT- HEMO2life® would therefore partly overcome the dramatic shortage of cardiac grafts. INOVAGRAFT is an imaging compatible device that would also enable the evaluation of the graft viability by multimodal imaging: MRI, Ultrasound, X, and PET in order to characterize: - (a) edema and tissue hardening - (b) microperfusion and vascular permeability - (c) energy status of the graft.
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