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NeOClick
Development of New OrganoClick reactions using fluorogenicity
FunderFrench National Research Agency (ANR)
Funder Contribution €449,967.00
DurationFrom 01 Jan 2026
Project codeANR-25-CE07-3344
Identifiers
Description
The NeOClick project aims to develop new organocatalyzed cycloaddition reactions based on strategies employing fluorescence. This will enable a large number of catalysts and conditions to be tested via high-throughput screening. The partners involved in the OrganoClick reactions are activated ketones that will be transiently transformed into enamines in order to react with dipoles or dienes. The project is divided into 3 distinct tasks: 1) the development of OrganoClick reactions using either a fluorogenicity-based or a FRET-based strategy, 2) the development of Click & Release reactions using fluorogenicity-based cycloadditions in a bioorthogonality perspective, 3) the development of enantioselective versions of OrganoClick reactions. In each of these tasks, the phenomena associated with fluorescence will enable us to screen a large number of reaction parameters.
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The NeOClick project aims to develop new organocatalyzed cycloaddition reactions based on strategies employing fluorescence. This will enable a large number of catalysts and conditions to be tested via high-throughput screening. The partners involved in the OrganoClick reactions are activated ketones that will be transiently transformed into enamines in order to react with dipoles or dienes. The project is divided into 3 distinct tasks: 1) the development of OrganoClick reactions using either a fluorogenicity-based or a FRET-based strategy, 2) the development of Click & Release reactions using fluorogenicity-based cycloadditions in a bioorthogonality perspective, 3) the development of enantioselective versions of OrganoClick reactions. In each of these tasks, the phenomena associated with fluorescence will enable us to screen a large number of reaction parameters.
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