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TRANSION
FunderFrench National Research Agency (ANR)
Funder Contribution €574,995.00
DurationFrom 01 Feb 2013
Project codeANR-12-BS08-0023
Open Access mandatePublications: NoResearch data: No
Identifiers
Description
Our project aims at confining Ion Bio-Channel (IBC) in two different solid-state nanopores and at investigating their functional properties in terms of ionic permeability and selectivity. In other words, our goal is to build hybrid artificial/biological nanoporous systems exhibiting exceptional ion transport properties. Our project combines two subjects: (1) Synthesis of new artificial membranes Recent advances in membrane science allow the use of membranes in many fields such as food and agriculture, potable water production, industrial water treatment, biotechnology,..etc. Among the newly developed technologies, nanofiltration for liquids is one of the most promising. In that domain, one of the scientific and technical challenges is to develop nanoporous membranes with both ion permeability and selectivity higher than those of the existing systems. New materials for nanofiltration membranes are thus clearly needed. (2) Ion Bio-Channel Ionic bio-channels (IBC) insure the in- and out-exchange of ions (Na+, K+, ..) across living cells. Their properties in terms of ionic transport are exceptional since they exhibit fast ionic conductivity, i.e. permeability, and, at the same time, high ionic selectivity. Unfortunately, the transfer of their unique properties to artificial systems with mechanical strength high enough to ensure their practical use in various applications has neither been realized, nor even proposed, yet. Here, by coupling these two subjects, we propose to investigate at the nanoscopic levels completely new and potentially rich hybrid biological/solid-state nanoporous systems with both high ionic permeability and selectivity made of IBC confined inside cylindrical solid-state nanopores. The IBC considered in this project will be gramicidin-A (gA), amphotericin-B (AmB) and nystatin (NYST). The investigated two solid-state nanoporous systems are: (i) a 5µm thick track-etched polymer film with cylindrical nanopores (CNP) whose diameter (phi) is about 10 nm or less and (ii) a microfluidic device incorporating an ultra-long, i.e. a few hundreds of µm, individual single wall carbon nanotube (SWCNT) (phi=1-3 nm). In order to solve some of the scientific and methodological challenges associated with this project, a trans-disciplinary, i.e. biophysics/physics/chemistry, and trans-methodology (i.e. experiment/molecular simulation/analytical model) research consortium is proposed.
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Our project aims at confining Ion Bio-Channel (IBC) in two different solid-state nanopores and at investigating their functional properties in terms of ionic permeability and selectivity. In other words, our goal is to build hybrid artificial/biological nanoporous systems exhibiting exceptional ion transport properties. Our project combines two subjects: (1) Synthesis of new artificial membranes Recent advances in membrane science allow the use of membranes in many fields such as food and agriculture, potable water production, industrial water treatment, biotechnology,..etc. Among the newly developed technologies, nanofiltration for liquids is one of the most promising. In that domain, one of the scientific and technical challenges is to develop nanoporous membranes with both ion permeability and selectivity higher than those of the existing systems. New materials for nanofiltration membranes are thus clearly needed. (2) Ion Bio-Channel Ionic bio-channels (IBC) insure the in- and out-exchange of ions (Na+, K+, ..) across living cells. Their properties in terms of ionic transport are exceptional since they exhibit fast ionic conductivity, i.e. permeability, and, at the same time, high ionic selectivity. Unfortunately, the transfer of their unique properties to artificial systems with mechanical strength high enough to ensure their practical use in various applications has neither been realized, nor even proposed, yet. Here, by coupling these two subjects, we propose to investigate at the nanoscopic levels completely new and potentially rich hybrid biological/solid-state nanoporous systems with both high ionic permeability and selectivity made of IBC confined inside cylindrical solid-state nanopores. The IBC considered in this project will be gramicidin-A (gA), amphotericin-B (AmB) and nystatin (NYST). The investigated two solid-state nanoporous systems are: (i) a 5µm thick track-etched polymer film with cylindrical nanopores (CNP) whose diameter (phi) is about 10 nm or less and (ii) a microfluidic device incorporating an ultra-long, i.e. a few hundreds of µm, individual single wall carbon nanotube (SWCNT) (phi=1-3 nm). In order to solve some of the scientific and methodological challenges associated with this project, a trans-disciplinary, i.e. biophysics/physics/chemistry, and trans-methodology (i.e. experiment/molecular simulation/analytical model) research consortium is proposed.
