<< Background >>One of the biggest challenges is the availability of healthcare professionals that are able to use the latest information technologies developed in the big data analytics era (Rozman et al, 2016). The consortium therefor created an innovative, multilingual Massive Open Online Course on Bioinformatics providing it to the widest possible audience and integrating online Work Based Learning periods (Online Seminars).<< Objectives >>The BioS project aimed at advancing the skills of European medical doctors and other health professionals through the design, development and delivery of new modular vocational curricula on Digital Skills on Bioinformatics/Computational Biology, as well as transversal skills, straightforwardly responding to the skills gaps identified by existing research evidence.<< Implementation >>BioS has developed and delivered the BioS Vocational Open Online Course (VOOC) in accordance with ECVET/EQF/EQAVET and through the BioS Virtual Learning Environment (VLE) aiming to upgrade the transversal as well as occupation-specific skills of health care professionals in Medical chemistry (biomedical analysis), Medical statistics, Medical interpretation, and Clinical genetics, by introducing them to the use of Computational Biology for clinical applications.<< Results >>The project’s objectives were pursued through the following main results:- Modular Curricula integrating latest advancements in Computational Biology for the Healthcare sector - Training Material including, inter alia, video lectures, learning activities, assessment exams- Development of a Virtual Learning Environment (VLE) bringing together medical doctors, bioinformatics experts, educators, researchers and policy makers - Policy Briefs and Recommendations - Dissemination material