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BactiBot: Bacteria-based Hydrogel Microrobots for Enhanced Tissue Penetration and Cargo Delivery
FunderNetherlands Organisation for Scientific Research (NWO)
Duration15 Dec 2021 - 14 Dec 2022
Project codeOCENW.XS21.3.075
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Project timeline100%
Description
Micro and nanomotors, where an incorporated catalyst, enzymatic or inorganic in nature, ensures autonomous motion is a hot topic currently in multiple scientific disciplines. However, most catalysts are rarely biocompatible, preventing their use in human subjects. A superior method of motion is mechanical motion, where the rotation of flagella of organic cells causes propulsion. Herein, we aim to design a biohybrid micromotor through the encapsulation of microorganisms, such as the Escherichia coli (E. Coli) species. Harnessing these bacteria, and their ability to move towards food and thus responding to chemical gradients will directionally propel the motor using their flagella.
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Micro and nanomotors, where an incorporated catalyst, enzymatic or inorganic in nature, ensures autonomous motion is a hot topic currently in multiple scientific disciplines. However, most catalysts are rarely biocompatible, preventing their use in human subjects. A superior method of motion is mechanical motion, where the rotation of flagella of organic cells causes propulsion. Herein, we aim to design a biohybrid micromotor through the encapsulation of microorganisms, such as the Escherichia coli (E. Coli) species. Harnessing these bacteria, and their ability to move towards food and thus responding to chemical gradients will directionally propel the motor using their flagella.
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