Modulating anticorrelated networks in early Alzheimers disease a simultaneous TMS-fMRI approach

Promising approaches in Alzheimer?s disease (AD) research investigate the role of brain disconnection and network changes in disease development. Findings indicate that disruptions in the anticorrelated frontoparietal and default mode network play a role in this. However, the causal mechanisms underlying the network dynamics, and the causal involvement of network functionality in cognitive function have not yet been tested. The proposed project aims to investigate these causal mechanisms in healthy subjects and early AD patients, employing advanced neuroscientific methods, including simultaneous transcranial magnetic stimulation and functional imaging. Results will contribute to the understanding of AD and to future treatment development.