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Completed
EXPERIMENTAL EVOLUTION OF COMPLEX CELLS
FunderNetherlands Organisation for Scientific Research (NWO)
Duration14 May 2018 - 13 May 2022
Project codeALWOP.333
Identifiers
Project timeline100%
Description
Evolutionary changes occur via the slow accumulation of mutations. However, sudden changes can also occur via “major transitions” that give rise to new forms of organismal complexity. To understand this process, we developed a novel experimental system using bacterial cells that lack cell walls, called L-forms, which were fused to form polyploid cells. This fusion created a synthetic mutualism that allowed us to measure the context-dependent costs and benefits of cell-cell fusion and chromosomal coexistence. Our results are helping to understand the evolution of complex cells, similar to the transition that occurred at the origin of eukaryotes.
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Evolutionary changes occur via the slow accumulation of mutations. However, sudden changes can also occur via “major transitions” that give rise to new forms of organismal complexity. To understand this process, we developed a novel experimental system using bacterial cells that lack cell walls, called L-forms, which were fused to form polyploid cells. This fusion created a synthetic mutualism that allowed us to measure the context-dependent costs and benefits of cell-cell fusion and chromosomal coexistence. Our results are helping to understand the evolution of complex cells, similar to the transition that occurred at the origin of eukaryotes.
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