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Completed
Use of Omnimatch for template matching of 3D electron microscopy reconstructions
FunderNetherlands Organisation for Scientific Research (NWO)
Duration29 Jun 2007 - 30 Jan 2009
Project codeMP-07-141-V
Open Access mandatePublications: NoResearch data: No
Identifiers
Project timeline100%
Description
The computing cluster LISA will be used for calculation time using the program OmniMatch. This program allows us to locate specific templates in 3D electron microscopic reconstructions (tomograms) of biological samples. This is useful either to draw specific structures (for examples tubules in a cell) in a tomogram or to compute averages of these specific structures. We will apply this technique, among others, to follow tubules of the protein von Willebrand factor that are found in special secretory granules of endothelial cells called Weibel-Palade bodies. In addition to the drawing of the tubules we hope to further elucidate the 3D structures of these tubules by computing the average of these tubules.
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The computing cluster LISA will be used for calculation time using the program OmniMatch. This program allows us to locate specific templates in 3D electron microscopic reconstructions (tomograms) of biological samples. This is useful either to draw specific structures (for examples tubules in a cell) in a tomogram or to compute averages of these specific structures. We will apply this technique, among others, to follow tubules of the protein von Willebrand factor that are found in special secretory granules of endothelial cells called Weibel-Palade bodies. In addition to the drawing of the tubules we hope to further elucidate the 3D structures of these tubules by computing the average of these tubules.
