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Completed
Optical control of cyclic nucleotide breakdown via light-sensitive molecular switches
FunderNetherlands Organisation for Scientific Research (NWO)
Duration01 Sep 2020 - 31 Mar 2021
Project codeOCENW.XS2.068
Identifiers
Project timeline100%
Description
Optical control of biological processes is one of the holy grails in biology as it is non-invasive, dynamic and can be applied very locally. In this XS-proposal we aim to design, synthesise and evaluate light-switchable inhibitors of cyclic nucleotide phosphodiesterase PDE5, to allow such spatial-temporal control of this key regulator of cellular signalling. These tools will be synthesised and studied with respect to photochemical properties and their ability to show different biological activities upon photo-isomerization. Ultimately, suitable tools will allow to study the effects of local PDE5 inhibition in e.g. skin disorders, colon cancer and heart failure.
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Optical control of biological processes is one of the holy grails in biology as it is non-invasive, dynamic and can be applied very locally. In this XS-proposal we aim to design, synthesise and evaluate light-switchable inhibitors of cyclic nucleotide phosphodiesterase PDE5, to allow such spatial-temporal control of this key regulator of cellular signalling. These tools will be synthesised and studied with respect to photochemical properties and their ability to show different biological activities upon photo-isomerization. Ultimately, suitable tools will allow to study the effects of local PDE5 inhibition in e.g. skin disorders, colon cancer and heart failure.
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