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Ongoing (M44)
The role of de-ubiquitinating enzymes in tau-induced dysfunction of the neuronal auto- and endo-lysosomal system
FunderNetherlands Organisation for Scientific Research (NWO)
Duration01 Apr 2023 - 31 Dec 9999
Project codeOCENW.M.21.123
Open Access mandatePublications: NoResearch data: No
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Description
Most forms of dementia are characterized by clumping of the tau protein. In this project we will investigate how an important way to regulate protein degradation in brain cells is disrupted by tau clumping. The results of this study will provide detailed insight into how tau clumping leads to loss of neurons and will thus contribute to the development of a new target for therapy for dementia.
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Most forms of dementia are characterized by clumping of the tau protein. In this project we will investigate how an important way to regulate protein degradation in brain cells is disrupted by tau clumping. The results of this study will provide detailed insight into how tau clumping leads to loss of neurons and will thus contribute to the development of a new target for therapy for dementia.
