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Can nucleic acid-inspired, conductive matrices be a game changer for engineered heart tissue (EHT) models?
FunderNetherlands Organisation for Scientific Research (NWO)
DurationFrom 01 Sep 2025
Funded underOpen Competitie ENW XS pakket 25-1
Project codeOCENW.XS25.1.297
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Description
Globally, millions of people battle heart diseases, requiring new therapeutic approaches. Engineered heart tissue (EHT) devices are in vitro models combining cardiac cells, a hydrogel matrix and a microfluidic setup; used to study heart diseases and to screen new therapeutics. A challenge in EHT is replicating the heart’s natural electrical conductivity, crucial for synchronized contractions and preventing arrhythmias, but currently used hydrogel matrices are not conductive. Herein, innovative nucleic-acid inspired conductive hydrogels are proposed for EHT manufacturing to improve cell communication and electrical signaling, thus enabling physiologically relevant heart tissue models with the potential to transform millions of lives.
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Globally, millions of people battle heart diseases, requiring new therapeutic approaches. Engineered heart tissue (EHT) devices are in vitro models combining cardiac cells, a hydrogel matrix and a microfluidic setup; used to study heart diseases and to screen new therapeutics. A challenge in EHT is replicating the heart’s natural electrical conductivity, crucial for synchronized contractions and preventing arrhythmias, but currently used hydrogel matrices are not conductive. Herein, innovative nucleic-acid inspired conductive hydrogels are proposed for EHT manufacturing to improve cell communication and electrical signaling, thus enabling physiologically relevant heart tissue models with the potential to transform millions of lives.
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