3D spheroids and AI-driven modeling and simulations for lymphoma drug screening (3D-AIM)

Revolutionizing Lymphoma Treatment: 3D Models and AI for Personalized Care For over 2 decades, the standard treatment for aggressive lymphoma’s is chemo-immunotherapy, which is rather ineffective, immunosuppressive, and prone to relapse/resistance. Current lab models fail to reflect the complexity of this group of diseases. This project will develop a pipeline of advanced 3D laboratory models that mimic the tumor microenvironment, subsequently leveraging AI for feature extraction of biophysical characteristics, and driving simulations to predict dynamics and drug responses. This state-of-the-art approach seeks to improve treatment accuracy, reduce animal testing, and bring personalized medicine closer to reality for lymphoma patients.