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Ongoing
The fat perspective: High multi-resolution imaging of lipid metabolism
FunderNetherlands Organisation for Scientific Research (NWO)
Duration01 Aug 2019 - 31 Dec 9999
Project codeTTW VI.Vidi.198.011
Identifiers
Project timeline0.1%
Description
Fats (lipids) are major components of our cells, but seeing where they sit inside tissues and how they change over time (e.g. during disease) has been challenging with conventional technologies. This project developed new mass spectrometry imaging technology that maps lipids at much higher spatial resolution than previously possible. Using this new instrument incorporating numerous innovative elements lipids could be spatially mapped at 2 micrometer resolution. New methods were also developed to image near-identical lipid molecules with the same molecular weight, and track lipid metabolism in single cells. These advances offer powerful tools for research into health and disease.
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Fats (lipids) are major components of our cells, but seeing where they sit inside tissues and how they change over time (e.g. during disease) has been challenging with conventional technologies. This project developed new mass spectrometry imaging technology that maps lipids at much higher spatial resolution than previously possible. Using this new instrument incorporating numerous innovative elements lipids could be spatially mapped at 2 micrometer resolution. New methods were also developed to image near-identical lipid molecules with the same molecular weight, and track lipid metabolism in single cells. These advances offer powerful tools for research into health and disease.
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