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Completed
Exploring the heterogeneous genetic origins of alcohol misuse
FunderNetherlands Organisation for Scientific Research (NWO)
Duration01 Jul 2021 - 03 Feb 2025
Project codeVI.Veni.201G.064
Identifiers
Project timeline100%
Description
Alcohol misuse is a highly heritable behaviour with enormous global health burden and societal costs. In this study, we identified multiple sets of genes linked to alcohol use behaviors. The effects of these genes varied across the lifespan and were mediated through brain and behavioral traits. Different patterns of alcohol use behaviors were associated with different underlying genetic and neurobiological processes, indicating a need for individualized interventions. Considering these multiple pathways is critical to understanding individual differences in alcohol misuse.
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Alcohol misuse is a highly heritable behaviour with enormous global health burden and societal costs. In this study, we identified multiple sets of genes linked to alcohol use behaviors. The effects of these genes varied across the lifespan and were mediated through brain and behavioral traits. Different patterns of alcohol use behaviors were associated with different underlying genetic and neurobiological processes, indicating a need for individualized interventions. Considering these multiple pathways is critical to understanding individual differences in alcohol misuse.
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