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DNActuate: fundamentals of DNA nano-motions for molecular diagnostics
FunderNetherlands Organisation for Scientific Research (NWO)
DurationFrom 01 May 2025
Funded underNWO-Talentprogramma Vidi ENW 2023 ENW/Science
Project codeVI.Vidi.233.222
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Description
DNA en eiwitten zijn fantastische voorbeelden van moleculaire machines. Onderzoekers zullen een nieuw biofysisch platform ontwikkelen om de dynamiek en mechanica van biomoleculaire processen op het niveau van één molecuul in beeld te brengen en te beheersen. Door ultraplatte, biocompatibele 2D-materiaaloppervlakken te combineren met DNA-nanotechnologie, zullen ze met behulp van fluorescentiemicroscopietechnieken bestuderen hoe moleculen bewegen, interageren en functioneren. Ze zullen de opgedane fundamentele kennis gebruiken om nieuwe biosensoren te ontwikkelen die in staat zijn circulerend tumor-DNA te detecteren. Dit maakt het mogelijk om de progressie van kanker regelmatig te monitoren.
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DNA en eiwitten zijn fantastische voorbeelden van moleculaire machines. Onderzoekers zullen een nieuw biofysisch platform ontwikkelen om de dynamiek en mechanica van biomoleculaire processen op het niveau van één molecuul in beeld te brengen en te beheersen. Door ultraplatte, biocompatibele 2D-materiaaloppervlakken te combineren met DNA-nanotechnologie, zullen ze met behulp van fluorescentiemicroscopietechnieken bestuderen hoe moleculen bewegen, interageren en functioneren. Ze zullen de opgedane fundamentele kennis gebruiken om nieuwe biosensoren te ontwikkelen die in staat zijn circulerend tumor-DNA te detecteren. Dit maakt het mogelijk om de progressie van kanker regelmatig te monitoren.
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